Rejuvenate Bio is using a convergent, multi-disciplinary approach, combining gene therapy, proprietary targets, and the animal health market to bring human age-related therapies to market. We are targeting the core drivers of chronic age-related diseases by unlocking the power of gene expression and epigenetic reprogramming to reverse pre-existing heart disease, metabolic disease, and kidney failure in humans.

Each therapy we’re developing has the potential for therapeutic impact across multiple disease indications, with each new piece of data validating the approach and increasing the value of each clinical program. This will allow us to rapidly expand each product into multiple indications. Additionally, our animal health programs provide an untapped market for early revenue and further validation for use in humans.

We are seeking an innovative Scientist to join our Bioanalytical Development team! This position is ideal for recent Ph.D. graduates who are interested in pursuing a career in industry.The Scientist, Immunoassay Development will collaborate closely with the preclinical leadership team to develop and optimize immunogenicity assays for our AAV gene therapy programs. The successful candidate will play a key role in developing and validating assays to detect and quantify immune responses to AAV vectors in preclinical and clinical samples. The candidate should have a deep understanding of viral vector immunology, and experience with a variety of immunoassay platforms (ELISA, flow cytometry, etc.). This role reports to the Principal Scientist, Bioanalytical Development.

Responsibilities:

• Design and execute experiments to develop, optimize, and validate immunoassays for detection and quantification of immune responses to AAV vectors, including both antibody-mediated and cell-mediated immunogenicity.
• Develop and implement standardized protocols for preclinical sample handling and processing, including serum/plasma and PBMCs.
• Analyze data, troubleshoot technical issues, and propose solutions to optimize assay performance.
• Performing basic and advanced cell culture on a variety of cell lines and primary cells including hepatocytes and PBMCs. 
• Majority of time dedicated to performing experiments in the lab.
• Designing and executing experiments independently and in conjunction with cross-functional assay and product development teams in support multiple gene therapy programs. 
• Assist in the preparation of study reports for IND enabling studies for late-stage gene therapy candidates. 
• Foster cross-functional collaborations with academic institutions and CROs.
• Adhere to laboratory protocols and safety regulations.
• Meticulously document all experiments and laboratory practices via electronic lab notebook.
• Deliver on-time, high-quality results and effectively communicate progress clearly in group meetings.
• Perform any additional duties assigned by supervisor or manager.

• Ph.D. in Immunology, Biology, Biochemistry, Pharmacology, Physiology, or related discipline. Postdoc or industry experience is not required. We specifically seek a highly motivated recent Ph.D. graduate who wishes to forgo a postdoc and launch their career in industry. 
• Knowledge and experience with preclinical studies for AAV gene therapy or other viral vectors (both in vivo and in vitro) as well as immunology to viral vectors.
• Demonstrates a deep understanding of the principles of immunoassay development and validation, as well as experience with a variety of immunoassay platforms (i.e. ELISA, flow cytometry, Western blot and cell-based immunoassays like PBMC-ELISPOT assay).
• Extensive experience on different types of cell culture including primary cells and cell lines.
• Knowledge and experience with cell-based assay development.
• A knowledge of statistical analysis and data visualization software for large preclinical datasets.
• Ability to successfully do research independently with only a goal as input. 
• Excellent communication and interpersonal skills, with a demonstrated ability to work cross-functionally.

Base Salary: $100k - $120k+; exact salary and job title will depend on experience.

Physical Requirements:
The physical demands described here are representative of those that must be met by an employee to successfully perform the essential functions of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

• Position is primarily sedentary, and employee may be required to sit for extended periods of time.
• Standing, walking and meeting activities are required frequently throughout the workday.
• Must be able to process paperwork and utilize office equipment (including personal computer, phone, copiers, etc.).
• Normal sight or corrected vision is required to read documents and use standard computer terminals. Some light lifting may be occasionally required.
• Ability to safely and successfully perform the essential job functions consistent with the ADA, FMLA and other federal, state and local standards, including meeting qualitative and/or quantitative productivity standards.
• Ability to maintain regular, punctual attendance consistent with the ADA, FMLA and other federal, state and local standards
• Must be able to lift and carry up to 25 lbs
• Must be able to talk, listen and speak clearly on telephone

EEO Statement
Rejuvenate Bio is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Rejuvenate Bio is an E-Verify Employer in the United States. All your information will be kept confidential according to EEO guidelines.

The health and safety of our employees and their families is a top priority. The company encourages employees to remain up-to-date on their COVID-19 vaccinations. Rejuvenate Bio, Inc. employees may be required, in the future, to be vaccinated or have an approved disability/medical or religious accommodation.